MDB, 2013 Ruhsal Bozuklukların Tanısal ve Sayımsal El Kitabı, Beşinci Baskı (DSM-5) 1 veya Uluslararası Hastalık Sınıflandırması 10. Revizyonu (ICD-10) ruhsal ve davranışsal bozukluklar sınıflandırmasına göre sınıflandırılır.14
COVID-19 pandemisi, Avrupa'daki tüm yaş gruplarında, özellikle işini kaybetmiş olanlar arasında ruh sağlığında olumsuz etkiye neden olmuştur.26
Türkiye'de MDB prevalansı, COVID-19 pandemisi ile birlikte %38'in üzerinde artış göstermiştir.27
Dünya Sağlık Örgütü, ruh sağlığı sorunlarının dünya çapında işlevsellik kaybının önde gelen nedeni olduğunu bildirmektedir.28
Ayrıca, depresyonu olan hastaların iskemik kalp hastalığı geliştirme olasılığı genel popülasyona kıyasla 1,5 kattan fazladır.31
ACNP: Amerikan Nöropsikiyatri Koleji, DSM-5: Ruhsal Bozuklukların Tanısal ve Sayımsal El Kitabı, Beşinci Baskı, HAMD-17: Hamilton Depresyon Değerlendirme Ölçeği, ICD-10: Uluslararası Hastalık Sınıflandırması 10. Revizyon, MDB: Majör Depresif Bozukluk, TDD: Tedaviye Dirençli Depresyon.
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